Peak At Science: 2022 November 29

A Peak At The Science 2022 November 29
Open Access

Peak At Science: 2022 November 29

Photobiomodulation for Alzheimer’s Disease: Has the Light Dawned?

Next to cancer, Alzheimer’s disease (AD) and dementia is probably the most worrying health problem facing the Western world today. A large number of clinical trials have failed to show any benefit of the tested drugs in stabilizing or reversing the steady decline in cognitive function that is suffered by dementia patients. Although the pathological features of AD consisting of beta-amyloid plaques and tau tangles are well established, considerable debate exists concerning the genetic or lifestyle factors that predispose individuals to developing dementia. Photobiomodulation (PBM) describes the therapeutic use of red or near-infrared light to stimulate healing, relieve pain and inflammation, and prevent tissue from dying. In recent years PBM has been applied for a diverse range of brain disorders, frequently applied in a non-invasive manner by shining light on the head (transcranial PBM). The present review discusses the mechanisms of action of tPBM in the brain, and summarizes studies that have used tPBM to treat animal models of AD. The results of a limited number of clinical trials that have used tPBM to treat patients with AD and dementia are discussed.


癌の次に、アルツハイマー病(AD)と認知症は、おそらく今日の西洋世界が直面している最も心配な健康問題です。多数の臨床試験では、認知症患者が被った認知機能の安定または逆転において、検査された薬物の利点を示すことができませんでした。ベータアミロイドプラークとタウのもつれからなるADの病理学的特徴は十分に確立されていますが、個人が認知症の発症に耐える素因となる遺伝的またはライフスタイルの要因に関するかなりの議論が存在します。フォトビオモジュレーション(PBM)は、赤または近赤外光の治療的使用を説明し、治癒を刺激し、痛みと炎症を和らげ、組織が死ぬのを防ぎます。近年、PBMは多様な脳障害に適用されており、頭に光を当てることにより、非侵襲的な方法で頻繁に適用されます(経頭蓋PBM)。現在のレビューでは、脳におけるTPBMの作用メカニズムについて説明し、ADの動物モデルを治療するためにTPBMを使用した研究をまとめています。 TPBMを使用してADおよび認知症の患者を治療した限られた数の臨床試験の結果について説明します。

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