Peak At Science: 2022 December 6

A Peak At The Science 2022 December 5
Open Access

Peak At Science: 2022 December 6

Mechanisms and Mitochondrial Redox Signaling in Photobiomodulation

Photobiomodulation (PBM) involves the use of red or near-infrared light at low power densities to produce a beneficial effect on cells or tissues. PBM therapy is used to reduce pain, inflammation, edema, and to regenerate damaged tissues such as wounds, bones, and tendons. The primary site of light absorption in mammalian cells has been identified as the mitochondria and, more specifically, cytochrome c oxidase (CCO). It is hypothesized that inhibitory nitric oxide can be dissociated from CCO, thus restoring electron transport and increasing mitochondrial membrane potential. Another mechanism involves activation of light or heat-gated ion channels. This review will cover the redox signaling that occurs in PBM and examine the difference between healthy and stressed cells, where PBM can have apparently opposite effects. PBM has a marked effect on stem cells, and this is proposed to operate via mitochondrial redox signaling. PBM can act as a preconditioning regimen and can interact with exercise on muscles.


フォトビオモジュレーション(PBM)には、細胞または組織に有益な効果をもたらすために、低出力密度で赤または近赤外光を使用することが含まれます。 PBM療法は、痛み、炎症、浮腫を軽減し、傷、骨、腱などの損傷した組織を再生するために使用されます。 哺乳類細胞の光吸収の主要部位は、ミトコンドリア、より具体的にはシトクロムCオキシダーゼ(CCO)として同定されています。 阻害性一酸化窒素はCCOから解離し、電子輸送を回復し、ミトコンドリア膜電位を増加させると仮定されています。 別のメカニズムには、光または熱溶解イオンチャネルの活性化が含まれます。 このレビューでは、PBMで発生する酸化還元シグナル伝達をカバーし、PBMが明らかに反対の効果を持つことができる健康細胞とストレス細胞の違いを調べます。 PBMは幹細胞に顕著な効果があり、これはミトコンドリア酸化還元シグナル伝達を介して動作することが提案されています。 PBMは前処理レジメンとして機能し、筋肉の運動と相互作用することができます。

User Agreement

Welcome to Modern Samurai.

An important part of establishing a contract is meeting of the minds. Where many websites hide their user agreement (a.k.a. terms of use, terms of service) at the bottom of their pages, we prefer to be upfront and honest about what you’re getting into. Please download our User Agreement and review it. If you agree, click “Agree” to continue to this Site. If you do not agree, click “Decline” to move away from this Site.